Session Index

The challenge to decode the computing power of the brain brings our focus down to single brain cells or neurons. Specifically, we aim to identify the roles of the neuron’s dendrites in the processing of synaptic inputs, which eventually leads the neuron to fire an output.

 

In this study, we demonstrate a novel label-free biodetection platform utilizing an additional weak electric field across a sandwiched LC cell. The mentioned biosensing approach exploits both the electrical and optical properties of LCs. This platform applicable to other LC-based rapid screening and bioassays.

 

Neural circuit is the basis to know the information processing in the animal. A novel method integrate of sample clearing, microscopy and sectioning technology is presented to overcome the acquisition depth limitation of conventional optical microscope, establish a whole-Drosophila neural image to study the whole-body connectome of animal.

 

To image in vivo volumetric biological samples requires optical sectioning capability. Recently, we adapted light sheet microscopy to obtain optically sectioned images of a live Caenorhabditis elegans. Here, we further report compact holographic light sheet microscopic imaging to observe live Caenorhabditis elegans with high resolution in real time.

 

The surface plasma resonance (SPR) exhibits highly sensitive characteristics for refractive-index biosensors. The SPR sensitivity enhancement is proposed to utilize two Mach–Zehnder interferometers in parallel, one using a laser source to detect SPR effect and the other with a broadband source as a reference point, to gauge interferogram displacements.

 

We experimentally and numerically demonstrate the permutation effect of DNA bases on SERS spectra of ssDNA 3-mers adsorbed to a gold nanorod substrate. Our results indicate that SERS-based method used in conjunction with theoretical modeling may lead to a cost-effective optical scanning of DNA sequences.