Session Index

Advanced optical imaging techniques such as fluorescence imaging (FI), optical coherence tomography (OCT), and multiphoton microscopy (MPM) can be used for early detection of cancer in a miniature endoscopic system.

 

e have developed a high speed, and long-wavelength swept-source optical coherence tomography (SS-OCT) imaging system with a 1.7 µm wavelength-swept laser. With a specifically designed fiber-optic scanning microscope where two objectives with different magnification (5X and 10X), it allows multiscale and wide field-of-view imaging of the imaging tissue specimens.

 

We demonstrated a compact two-dimensional hexagonal photonic crystal biosensor with thin gold film coating. Surface plasmon polariton on the metal structure and phase matching of optical wave with the photonic crystal are considered when analyzing light-biomaterial interaction, which helps detecting small variations of the refractive index on the sensor surface.

 

We propose to apply polymer-stabilized liquid crystals (PSLCs) as the sensing element for protein detection. After irradiating ultraviolet light to perform the photopolymerization process, our results indicate that the limit of detection can be promoted due to the enhancement of the optical signal, derived from the light scattering.

 

To meet the urgent need of label-free neuropathological diagnostics in clinics, we have demonstrated the capability of a 1.26 µm laser excitation source based simultaneous detection of second and third harmonic generation to provide dual endogenous contrasts for Alzheimer’s disease hallmarks: Aβ plaques and neurofibrillary tangles along with axons/dendrites.

 

Optical clearing technique has been widely used to enhance the image quality and image depth. However, the optical clearing effects and mechanisms of in vivo human skin remain unclear. In this study, we demonstrate and compare the optical clearing effects of in vivo and ex vivo human skin.